The Silicon Cell:

Silicon Cell Initiative Amsterdam

IMBW (Institute for Molecular Biological Sciences); Vrije Universiteit (VU)
theoretical and experimental molecular biology
coordinator: Hans V. Westerhoff; hw@bio.vu.nl; URL: www.bio.vu.nl/html/cell_phy.html
SILS (Swammerdam Institute for Life Sciences); University of Amsterdam (UvA)
theoretical and experimental molecular biology
contact: Roel van Driel; van.driel@chem.uva.nl; URL: www.science.uva.nl/sils/
IvI (Informatics Institute); University of Amsterdam (UvA)
computational physics
contact: Jaap Kaandorp; jaapk@science.uva.nl; URL: www.science.uva.nl/research/scs/
CWI (National Research Institute for Mathematics and Computer Science)
applied and numerical mathematics, control and system theory, visualization
contact: Joke Blom; gollum@cwi.nl; URL: www.cwi.nl/projects/pdels

Research focus

• regulatory networks (metabolic, signal transduction, gene expression)
• structure and functional organization of cell nucleus
• dynamic architecture of cells

Model integration to calculate two real cells

• E. coli (prokaryote)
• S. Cerevisiae (baker's yeast, eukaryote)